I gots me first rejection letter today. I expect I'll get one for every query I send out, if I'm lucky. Apparently not all agents send them. They just toss your letter (or email) into the rubbish bin and get on with their day.
Even though it was expected, it's hard not to take it personally. It's not unlike watching your kid left out of the game the other kids are playing. My characters have been hanging around in my brain for almost a year now and now they've been officially rejected.
A while back I read an article about every basement needing a first novel. I don't have a basement, but I suppose a garage will do.